Our research focuses on the electric behavior of neurons and neuronal networks under normal and pathological conditions. Using high-resolution neurophysiological and optical techniques, we investigate functions and regulation of ion channels and synapses. Our aim is to understand fundamental neural processes that are essential for cognitive functions as well as for affective behavior, and whose dysfunctions
might give rise to neuropsychiatric disorders. Specifically, we are studying the following topics:
- Role of activin, a member of the Transforming Growth Factor-β family, as a ”master molecule” tuning glutamatergic and GABAergic neurotransmission, and its impact on cognition, emotions and neuroprotection.
- Interaction between BACE1, a crucial enzyme in the amyloid cascade of Alzheimer’s disease, and properties and expression of Na+ and K+ channels. Physiological functions of BACE1.
- Neuropsychiatric disease models and mechanisms of drug action (in collaboration with the Department of Psychiatry and Psychotherapy).
MD students / Master students